Eastern mud turtles are small turtles and will do well in captivity, provided they are given the opportunity to access land. Thus, this species is a good candidate for a display containing both aquatic and terrestrial habitats. They may spend a good amount of time buried under humus and leaves, and thus be out of sight. Eastern mud turtles may sometimes bite and can deliver a painful nip with their sharp, hooked beak.

Eastern mud turtles require shallow water and are not strong swimmers. They rarely bask, if ever.

Eastern mud turtles are carnivorous and will eat small insects, tadpoles and earthworms. They will readily accept chopped meat and fish.